Rabbit anti-GLP-1R antibody, mouse anti-glial fibrillary acidic protein (GFAP) and mouse anti-alpha smooth muscle actin ( -SMA) were from Abcam PLC (Cambridge, UK), Goat anti-type I collagen antibody from Southern Biotechnology (Birmingham, AL, USA), rabbit antibody against glyceraldehydes-3-phosphate dehydrogenase (GAPDH) from Trevigen (Gaithersburg, MD, USA) and anti-rabbit IgG Alexa488-conjugated antibody, anti-mouse-IgG-Alexa555-conjugated antibody, anti-goat-IgG-Alexa350-conjugated antibody and Hoechst33342 were from Invitrogen (Carlsbad, CA, USA)
IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline
Recently, we generated mitochondria-deficient cells by introducing the E3 ligase Parkin and inducing mitochondria uncoupling with carbonyl cyanide m-chlorophenyl hydrazone (CCCP)
By bridging these gaps, GLP-1RAs could herald a new era in pain management, offering hope for patients with refractory or complex pain conditions
Target the human alanine/serine/cysteine transporter 2 (ASCT2): achievement and future for novel cancer therapy
